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Modeling Chemotherapy Resistant Leukemia In Vitro
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Does celiac disease influence survival in lymphoproliferative malignancy?

Jonas F Ludvigsson1, Benjamin Lebwohl, Alberto Rubio-Tapia

  • 1Clinical Epidemiology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden. jonasludvigsson@yahoo.com

European Journal of Epidemiology
|March 7, 2013
PubMed
Summary

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Celiac disease (CD) patients with lymphoproliferative malignancy (LPM) do not have a worse survival rate than those without CD. The initial increased mortality risk in CD+LPM patients is linked to T-cell non-Hodgkin lymphoma.

Area of Science:

  • Oncology
  • Immunology
  • Gastroenterology

Background:

  • Celiac disease (CD) is linked to lymphoproliferative malignancy (LPM) and increased LPM-related mortality.
  • Autoimmune conditions may impact survival in LPM patients.

Purpose of the Study:

  • To investigate the impact of co-existing celiac disease (CD) on overall and cause-specific mortality in patients diagnosed with lymphoproliferative malignancy (LPM).

Main Methods:

  • Cox regression analysis was used to compare mortality rates between 316 individuals with CD+LPM and 689 individuals with LPM only.
  • Celiac disease was defined by biopsy-confirmed villous atrophy; LPM was identified via Swedish Cancer Register codes.

Main Results:

  • Individuals with CD+LPM showed an increased overall risk of death (aHR=1.23) compared to LPM-only patients, primarily within the first year post-diagnosis (aHR=1.76).

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  • The excess mortality risk diminished in subsequent years.
  • CD patients with non-Hodgkin lymphoma (NHL) had a higher risk of death, attributed to a predominance of T-cell lymphomas.

    • Conclusions:

    • Co-existing celiac disease does not appear to influence long-term survival in patients with lymphoproliferative malignancy.
    • The initial elevated mortality risk in CD+LPM patients is associated with a higher prevalence of T-cell non-Hodgkin lymphoma.
    • Patients with CD+LPM generally share a similar prognosis to LPM-only patients, though further research is needed for specific subtypes.