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Intracranial hemangiopericytoma: MR imaging findings and diagnostic usefulness of minimum ADC values
Gang Liu1, Zhi-Ye Chen, Lin Ma
1Department of Radiology, People's Liberation Army General Hospital, China.
Purpose:
To describe the clinical and magnetic resonance (MR) imaging features of primary intracranial hemangiopericytoma (HPC), and to assess the usefulness of minimum apparent diffusion coefficient (MinADC) value of HPC in the differential diagnosis from meningioma.
Materials And Methods:
From 2004 to 2010, fifteen patients with primary intracranial HPC were included. The clinical data, conventional MR findings (n = 15), and diffusion weighted image (DWI) features (n = 10) were retrospectively analyzed. MinADC value of the HPCs (n = 10) was measured on ADC map and was compared with that of meningiomas (n = 37).
Results:
In 15 cases of HPC, isointense signal was detected on both T1-weighted images (T1WI) and T2-weighted images (T2WI) in 11 cases, and heterogeneous signal was demonstrated in 4 cases. Isointensity (n = 9) and iso- and slight hyperintensity (n = 1) were shown on DWI. The mean MinADC value of HPC [(1.116 ± 0.127) × 10(-3) mm(2) /s] was significantly higher than that of meningioma [(0.875 ± 0.104) × 10(-3) mm(2) /s] (P < 0.01). For the differentiation between HPC and meningioma, the critical cutoff MinADC value was 0.991 × 10(-3) mm(2) /s, which provided the best combination of sensitivity (88.9%) and specificity (82.4%).
Conclusion:
MinADC value may be an useful tool for the differentiation between HPC and meningioma.
Insights
Minimum apparent diffusion coefficient (MinADC) values can help differentiate hemangiopericytoma (HPC) from meningioma. Higher MinADC values in HPC suggest it is a useful diagnostic tool in neuroimaging.
Area of Science:
- Neuroimaging
- Oncology
- Radiology
Background:
- Primary intracranial hemangiopericytoma (HPC) and meningioma are tumors that can present with similar imaging features.
- Accurate differentiation is crucial for appropriate treatment planning.
Purpose of the Study:
- To characterize the clinical and magnetic resonance (MR) imaging features of intracranial HPC.
- To evaluate the utility of minimum apparent diffusion coefficient (MinADC) values in distinguishing HPC from meningioma.
Main Methods:
- Retrospective analysis of 15 patients with intracranial HPC and 37 with meningioma.
- Conventional MR imaging and diffusion-weighted imaging (DWI) were reviewed.
- MinADC values were measured and compared between the two tumor types.
Main Results:
- HPC and meningioma exhibited overlapping conventional MR and DWI signal characteristics.
- The mean MinADC value for HPC (1.116 × 10⁻³ mm²/s) was significantly higher than for meningioma (0.875 × 10⁻³ mm²/s) (P < 0.01).
- A MinADC cutoff value of 0.991 × 10⁻³ mm²/s achieved 88.9% sensitivity and 82.4% specificity for differentiating HPC from meningioma.
Conclusions:
- Minimum apparent diffusion coefficient (MinADC) is a valuable quantitative imaging biomarker.
- MinADC can aid in the differential diagnosis between intracranial hemangiopericytoma and meningioma, improving diagnostic accuracy.
