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Cryo-electron Microscopy01:28

Cryo-electron Microscopy

Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...
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A cryogenic scattering-type scanning near-field optical microscope.

Honghua U Yang1, Erik Hebestreit, Erik E Josberger

  • 1Department of Physics, Department of Chemistry, and JILA, University of Colorado, Boulder, Colorado 80309, USA.

The Review of Scientific Instruments
|March 8, 2013
PubMed
Summary

We developed a versatile cryogenic scattering-type scanning near-field optical microscopy (s-SNOM) instrument for nanoscale optical spectroscopy. This advanced s-SNOM system probes quantum materials under extreme conditions, revealing domain formation during metal-insulator transitions.

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Area of Science:

  • Materials Science
  • Condensed Matter Physics
  • Optical Spectroscopy

Background:

  • Scattering-type scanning near-field optical microscopy (s-SNOM) offers nanoscale optical resolution.
  • Its compatibility with various spectroscopic techniques is crucial for advanced material characterization.

Purpose of the Study:

  • To develop a versatile s-SNOM instrument capable of operating under cryogenic temperatures and high magnetic fields.
  • To enable advanced spectroscopic studies of quantum materials and their phase transitions.

Main Methods:

  • Designed and implemented a novel s-SNOM instrument with independent tip/sample scanning and broad spectral range (UV to THz).
  • Integrated cryogenic (20-500 K) and high magnetic field (up to 7 T) capabilities.
  • Utilized mid-infrared spectroscopy to probe metal-insulator transitions in VO2 and V2O3.

Main Results:

  • Demonstrated the instrument's capability to probe domain formation during metal-insulator transitions.
  • Successfully characterized the Drude response associated with these transitions.
  • Showcased the system's versatility for various spectroscopic techniques, including tip-enhanced spectroscopy.

Conclusions:

  • The developed cryogenic, high-field s-SNOM instrument is a powerful tool for studying mesoscopic order in correlated electron materials.
  • Enables investigation of competing quantum phases under controlled external stimuli (fields, temperature, strain, current).
  • Opens new avenues for nanoscale optical spectroscopy of quantum phenomena.