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Lack of increased P15INK4B protein expression in basal cell carcinomas

Ahmed Ismail Hassan Moad1, Mei Lan Tan, Gurjeet Kaur

  • 1Advanced Medical and Dental Institute, University Sains Malaysia, Penang, Malaysia. mohamed.mabruk@.ubd.edu.bn

Asian Pacific Journal of Cancer Prevention : APJCP
|March 8, 2013
PubMed
Abstract

Insights

Basal cell carcinoma (BCC) is a common skin cancer. This study found that p15INK4b protein expression did not differ between BCC and normal skin, suggesting it may not be involved in BCC development.

Area of Science:

  • Oncology
  • Dermatology
  • Molecular Biology

Background:

  • Basal cell carcinoma (BCC) is the most prevalent non-melanoma skin cancer (NMSC).
  • Faulty cell cycle arrest is implicated in BCC development.
  • p15INK4b, a tumor suppressor gene, is crucial for cell cycle arrest and frequently inactivated in cancers.

Purpose of the Study:

  • To investigate the role of p15INK4b protein expression in the pathogenesis of Basal Cell Carcinoma (BCC).
  • To determine if p15INK4b expression differs between BCC and normal skin tissues.

Main Methods:

  • Immunohistochemical analysis was employed to assess p15INK4b protein expression.
  • The study included 35 cases of BCC tissue arrays and 19 cases of normal human skin tissue.

Main Results:

  • No significant difference in p15INK4b protein expression was observed between BCC cases and normal human skin (p=0.356).
  • p15INK4b expression showed no significant correlation with clinicopathological variables such as patient age and sex.

Conclusions:

  • The findings suggest that p15INK4b protein expression is unlikely to play a significant role in the genesis of Basal Cell Carcinoma.
  • Further research may be needed to explore other potential molecular mechanisms in BCC development.

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