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Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
The Ras Gene02:38

The Ras Gene

The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a superfamily...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

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Related Experiment Video

Updated: May 13, 2026

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
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Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

RGS expression in cancer: oncomining the cancer microarray data.

Nan Sethakorn1, Nickolai O Dulin

  • 1Department of Medicine, The University of Chicago, Chicago, IL, USA.

Journal of Receptor and Signal Transduction Research
|March 8, 2013
PubMed
Summary
This summary is machine-generated.

Regulators of G protein Signaling (RGS) proteins show altered expression in various cancers. Some RGS proteins are consistently up or down regulated, suggesting common mechanisms in cancer progression.

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Development of Compendium for Esophageal Squamous Cell Carcinoma
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Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

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Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
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Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

Development of Compendium for Esophageal Squamous Cell Carcinoma
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Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

Area of Science:

  • Molecular Biology
  • Oncology
  • Cell Signaling

Background:

  • Heterotrimeric G proteins regulate crucial cell functions, including cancer cell proliferation and migration.
  • Regulators of G protein Signaling (RGS) proteins modulate G protein activity by accelerating GTPase activity.
  • Altered RGS protein expression is increasingly implicated in various cancers.

Purpose of the Study:

  • To investigate common trends in the expression of RGS proteins across different cancer types.
  • To analyze the expression patterns of the RGS R4 sub-family in various malignancies.
  • To identify potential shared regulatory mechanisms of RGS proteins in cancer progression.

Main Methods:

  • Utilized Oncomine database to examine microarray data for RGS protein expression.
  • Focused analysis on the R4 sub-family of RGS proteins (RGS1, RGS2, RGS3, RGS4, RGS5, RGS8, RGS13, RGS16, RGS18).
  • Compared RGS transcript expression levels across multiple cancer types.

Main Results:

  • Identified specific RGS transcripts that are exclusively downregulated in some cancers and upregulated in others.
  • Observed consistent directional changes in expression for certain RGS proteins across various cancers.
  • RGS1 is predominantly upregulated, RGS2 downregulated in most solid tumors, and RGS5 upregulated in lymphoma subtypes.

Conclusions:

  • RGS proteins likely play combined and cell-specific roles in controlling cancer cell functions.
  • Individual RGS proteins may influence the progression of diverse cancers via common mechanistic pathways.
  • Expression patterns of RGS proteins offer insights into their multifaceted roles in oncogenesis.