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Updated: May 13, 2026
09:45
Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
Published on: October 28, 2015
Platelets, photosensitizers, and PDT
Mathias O Senge1, Marek W Radomski
1Medicinal Chemistry, Institute of Molecular Medicine, Trinity Centre for Health Sciences, Trinity College Dublin, St James's Hospital, Dublin 8, Ireland. sengem@tcd.ie
Photodiagnosis and Photodynamic Therapy
|March 8, 2013
Summary
Photodynamic therapy (PDT) impacts cells and blood vessels, offering anti-angiogenesis potential. This review explores PDT
Area of Science:
- Vascular Biology
- Photodynamic Therapy
- Oncology
Background:
- Photodynamic therapy (PDT) exhibits direct cellular and indirect vascular effects.
- Targeting angiogenesis is a key strategy in PDT treatments.
- Understanding PDT's microvasculature effects is crucial for anti-angiogenesis advancements.
Purpose of the Study:
- To review PDT's effects on platelets and vascular endothelial cells.
- To highlight the emerging role of platelet-endothelial cell interactions in PDT.
- To identify potential research directions in PDT and vascular signaling.
Main Methods:
- Literature review of studies on PDT, platelets, and endothelial cells.
- Analysis of signaling pathways involved in PDT-induced vascular effects.
- Synthesis of current knowledge on PDT's impact on angiogenesis.
Main Results:
- PDT influences platelet aggregation and endothelial cell interactions.
- Signaling pathways mediating these interactions are increasingly recognized.
- PDT's vascular effects offer therapeutic potential beyond direct tumor cell killing.
Conclusions:
- PDT's vascular effects, particularly on platelets and endothelial cells, are critical for anti-angiogenesis strategies.
- Further research into platelet-endothelial cell crosstalk in PDT is warranted.
- Understanding these interactions can optimize PDT for cancer treatment.
