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Armand Cholewka1, Agata Stanek, Sebastian Kwiatek
1Institute of Physics, Department of Medical Physics, University of Silesia, Uniwersytecka 4, 40-007 Katowice, Poland. armand.cholewka@gmail.com
Photodiagnosis and Photodynamic Therapy
|March 8, 2013
Summary
Infrared thermography combined with photodynamic diagnosis (PDD) can differentiate basal cell carcinoma (BCC) from benign seborrhoeic keratosis. BCC lesions show higher thermal mapping temperatures, while keratosis lesions appear cooler than surrounding skin.
Area of Science:
- Dermatology
- Medical Imaging
- Oncology
Background:
- Basal cell carcinoma (BCC) is the most common skin cancer, while seborrhoeic keratosis is a frequent benign skin tumor.
- Non-invasive optical diagnosis techniques like photodynamic diagnosis (PDD) and thermovision are crucial for skin lesion assessment.
- Differentiating between BCC and seborrhoeic keratosis is clinically significant.
Purpose of the Study:
- To evaluate infrared thermography as an adjunct to PDD for distinguishing basal cell carcinoma from seborrhoeic keratosis.
- To investigate thermal mapping differences between cancerous and benign skin lesions.
Main Methods:
- Utilized the Xillix Onco system for photodynamic diagnosis (PDD).
- Employed a Thermovision Camera A40M for thermal imaging with 0.07K sensitivity.
- Studied 13 skin lesions (9 BCC, 4 seborrhoeic keratosis) under controlled temperature conditions (22.5±1°C).
- Histopathological examination confirmed all diagnoses.
Main Results:
- Significant differences in skin thermal mapping were observed between BCC and seborrhoeic keratosis.
- Benign seborrhoeic keratosis lesions exhibited lower mean temperatures than surrounding healthy skin.
- Malignant basal cell carcinoma lesions displayed higher mean temperatures on thermal maps.
Conclusions:
- Infrared thermography provides additional diagnostic information when combined with PDD.
- Thermal imaging characteristics correlate with PDD findings for skin lesion differentiation.
- This combined approach aids in distinguishing between basal cell carcinoma and seborrhoeic keratosis.
