Related Experiment Video

Updated: May 13, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

Arterial ischemic stroke and hemorrhagic stroke in Chinese children: a retrospective analysis

Ling-Ling Xie1, Li Jiang1

  • 1Department of Neurology, Children's Hospital of Chongqing Medical University, Chongqing, PR China.

Brain & Development
|March 8, 2013
PubMed

Insights

Hemorrhagic stroke (HS) is more common in Chinese children than arterial ischemic stroke (AIS). Vitamin K deficiency is a primary cause of HS in infants, while minor head injuries often precede AIS.

Area of Science:

  • Pediatric Neurology
  • Neuroscience
  • Public Health

Background:

  • Stroke is a significant cause of childhood morbidity and mortality.
  • Understanding the specific characteristics, etiologies, and risk factors of pediatric stroke subtypes is crucial for effective prevention and treatment.

Purpose of the Study:

  • To investigate the clinical features, etiological factors, and risk factors of pediatric arterial ischemic stroke (AIS) and hemorrhagic stroke (HS) in Southwest China.
  • To compare the incidence and characteristics of AIS and HS in the pediatric population.

Main Methods:

  • Retrospective review of medical records for pediatric patients diagnosed with AIS or HS between January 2003 and March 2011 at Children's Hospital of Chongqing Medical University.
  • Statistical analysis using SPSS 17.0, including Chi-squared tests to examine relationships between stroke types, sex, age, and neuroradiological findings.

Main Results:

  • A total of 169 pediatric stroke cases were analyzed (119 boys, 50 girls).
  • Hemorrhagic stroke (HS) was more prevalent (64.1%) than arterial ischemic stroke (AIS) (35.3%).
  • Vitamin K deficiency was the main cause of HS (59.6%), particularly in breastfed infants without postnatal vitamin K supplementation. Minor head injury was a common preceding factor for AIS (40.0%).

Conclusions:

  • Hemorrhagic stroke is the predominant type of stroke in children in Southwest China.
  • Vitamin K deficiency is a critical, preventable cause of HS in infants.
  • Minor head trauma is a significant risk factor for AIS in children, highlighting the need for protective measures.

Keywords:
Arterial ischemic strokeChildrenChineseEtiologyHemorrhagic stroke

More Related Videos

Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats07:56

Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats

Published on: April 21, 2017

Related Concept Videos

Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Stroke: Introduction and Types01:29

Stroke: Introduction and Types

A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...