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Updated: May 13, 2026

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
Published on: May 21, 2013
Managing the cystic osteochondral defect: allograft or autograft
Graham A McCollum1, Mark S Myerson, Jacques Jonck
1The Institute for Foot and Ankle Reconstruction, Mercy Medical Center, 301 St Paul Place, Baltimore, MD 21202, USA. grahammac@discoverymail.co.za
Abstract:
Osteochondral lesions of the talus are generally benign, and many heal or are not symptomatic. A subset of these defects progress to large cystic lesions, which have a less favorable prognosis. The treatment options are joint preservation or sacrifice. Joint salvage entails marrow stimulation techniques or hyaline cartilage replacement with allograft or autograft. When lesions reach greater than 3 cm(2) or Raikin class IV or become uncontained on the shoulders of the talus, autografting techniques become more challenging. Osteochondral allografting may be a better surgical option, often achievable without a malleolar osteotomy for exposure.
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