Related Experiment Video
Updated: May 13, 2026

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
Published on: September 17, 2020
25 years after age-1: genes, interventions and the revolution in aging research
1Institute for Behavioral Genetics, Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA. Thomas.Johnson@colorado.edu
Abstract:
This communication will briefly review more than 30 years of research on aging using the nematode Caenorhabditis elegans ("The Worm") as carried out in the labs of Tom Johnson. We will highlight research directions initiated in the 1980's, which were exciting for those of us trying to turn over a new leaf in aging research. In this narrative, I will discuss primarily the science that I and my lab have been involved with for the last 30 years. This area has been fascinating to those studying the sociology of science as modern aging research has moved to replace the simplistic, poorly controlled and outright fictitious approaches seen in much of the previous aging research.
Related Concept Videos
Aging
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Mitochondria
Telomeres and Telomerase
The Effect of Aging on Tissues
Replicative Cell Senescence
Replicative Cell Senescence

