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Related Concept Videos

Neuroplasticity01:01

Neuroplasticity

Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
Long-term Potentiation01:25

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...
Long-term Potentiation01:35

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Plasticity00:58

Plasticity

Plasticity is the property where an object loses its elasticity and undergoes irreversible deformation, even after the deformation forces are eliminated. If a material deforms irreversibly without increasing stress or load, then this is called ideal plasticity. For example, when a force is applied to an aluminum rod, it changes its shape, but it does not return to its original shape once the force is removed. Plastic deformation or ductility is thus a permanent deformation or change in the...
Long-term Depression01:03

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over time, all...
Long-term Depression01:05

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.

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Related Experiment Video

Updated: May 13, 2026

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus
05:01

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus

Published on: September 20, 2024

Experience-dependent homeostatic synaptic plasticity in neocortex.

Jessica L Whitt1, Emily Petrus1, Hey-Kyoung Lee1

  • 1The Solomon H. Snyder Department of Neuroscience, The Zanvyl-Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218, USA.

Neuropharmacology
|March 8, 2013
PubMed
Summary
This summary is machine-generated.

Neural circuits adapt via Hebbian plasticity (LTP/LTD) for learning and memory. Homeostatic plasticity stabilizes these processes, ensuring proper function within the neocortex and sensory cortex.

Keywords:
Cross-modal synaptic plasticityHomeostatic synaptic plasticitySensory cortexSensory deprivationSensory plasticitySliding thresholdSynaptic scalingVisual cortex

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Last Updated: May 13, 2026

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus
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Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
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Published on: August 11, 2019

Area of Science:

  • Neuroscience
  • Synaptic Plasticity
  • Homeostatic Adaptation

Background:

  • The nervous system adapts to environmental changes through experience-dependent neural modifications.
  • Hebbian plasticity, including long-term potentiation (LTP) and long-term depression (LTD), is crucial for neural circuit development and memory formation.
  • Synaptic plasticity mechanisms like LTP/LTD are inherently unstable, necessitating homeostatic regulation for neuronal function.

Purpose of the Study:

  • To review known mechanisms of experience-induced homeostatic synaptic plasticity in the neocortex.
  • To explore the functional roles of these homeostatic mechanisms in sensory cortex plasticity.

Main Methods:

  • Literature review focusing on homeostatic synaptic plasticity.
  • Analysis of mechanisms within the neocortex, particularly the sensory cortex.

Main Results:

  • Identified various homeostatic adaptation modes, some operating at the synaptic level.
  • Highlighted the necessity of homeostatic plasticity for stabilizing Hebbian plasticity.
  • Discussed the integration of homeostatic plasticity in sensory cortex function.

Conclusions:

  • Homeostatic synaptic plasticity is essential for maintaining neuronal function and enabling adaptive changes in the neocortex.
  • Understanding these mechanisms is key to comprehending sensory cortex plasticity and learning.