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Related Concept Videos

Fats as Energy Storage Molecules01:06

Fats as Energy Storage Molecules

Triglycerides are a form of long-term energy storage molecules. They are made of glycerol and three fatty acids. To obtain energy from fat, triglycerides must first be broken down by hydrolysis into their two principal components, fatty acids and glycerol. This process, called lipolysis, takes place in the cytoplasm. The resulting fatty acids are oxidized by β-oxidation into acetyl-CoA, which is used by the Krebs cycle. The glycerol that is released from triglycerides after lipolysis directly...
Fats as Energy Storage Molecules01:06

Fats as Energy Storage Molecules

Triglycerides are a form of long-term energy storage molecules. They are made of glycerol and three fatty acids. To obtain energy from fat, triglycerides must first be broken down by hydrolysis into their two principal components, fatty acids and glycerol. This process, called lipolysis, takes place in the cytoplasm. The resulting fatty acids are oxidized by β-oxidation into acetyl-CoA, which is used by the Krebs cycle. The glycerol that is released from triglycerides after lipolysis directly...
Hypodermis01:02

Hypodermis

The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
Lipid Digestion01:06

Lipid Digestion

Lipids are large molecules that are generally not water-soluble. Since most of the digestive enzymes in the human body are water-based, there are specific steps the body must take to break down lipids and make them available for use.

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Related Experiment Video

Updated: May 13, 2026

Innovative Adipose Tissue Fractionation for Transforming Fat into Specialized Components
04:36

Innovative Adipose Tissue Fractionation for Transforming Fat into Specialized Components

Published on: July 11, 2025

Get the fat out!

Natalia A Ignatenko1, Eugene W Gerner

  • 1Arizona Cancer Center, 1515 N Campbell Ave, P.O. Box 245024, Tucson, AZ 85724, USA. egerner@azcc.arizona.edu

Cancer Prevention Research (Philadelphia, Pa.)
|March 8, 2013
PubMed
Summary

Obesity increases cancer risk. Surgical removal of visceral fat reduced intestinal tumors in female mice, suggesting abdominal obesity may drive cancer development, warranting further research.

Area of Science:

  • Oncology
  • Metabolic Syndrome Research
  • Cancer Prevention

Background:

  • Obesity is linked to increased human cancer risk, but underlying mechanisms remain unclear.
  • An estimated 68% of US adults are overweight or obese, contributing to 4-7% of cancers.
  • Hypotheses include adipose signaling, growth factor production, and chronic inflammation.

Purpose of the Study:

  • To investigate the causal relationship between visceral fat and intestinal tumorigenesis.
  • To assess this relationship independently of confounding factors like caloric restriction.
  • To utilize the Apc(1638/N+) mouse model for studying obesity and cancer.

Main Methods:

  • Surgical removal of visceral fat in Apc(1638/N+) mice.
  • Assessment of survival rates and intestinal macroadenoma development.

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  • Comparison of outcomes between male and female mice.

    • Main Results:

    • Caloric restriction improved survival in both male and female mice.
    • Surgical visceral fat removal reduced macroadenomas only in female mice.
    • The specific mechanism linking visceral fat to intestinal cancer in females was not identified.

    Conclusions:

    • Visceral fat may causally contribute to intestinal carcinogenesis, particularly in females.
    • Findings support future trials targeting abdominal obesity reduction for cancer prevention.
    • Further research is needed to elucidate the precise mechanisms involved.