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Three risk factors for WHO grade II and III meningiomas: A study of 1737 cases from a single center

Peizhi Zhou1, Weichao Ma, Senlin Yin

  • 1Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.

Neurology India
|March 8, 2013
PubMed
Abstract

Insights

Younger males and pediatric patients are more prone to high-grade meningiomas. Tumors located laterally or away from the skull base also indicate a higher risk of aggressive meningioma (WHO grade II/III).

Area of Science:

  • Neurosurgery
  • Oncology
  • Pathology

Background:

  • Meningiomas represent a significant portion of central nervous system (CNS) tumors.
  • A substantial percentage (21-37.8%) are high-grade (atypical or anaplastic/malignant), associated with poorer outcomes.
  • Early assessment of tumor biology is crucial for effective management.

Purpose of the Study:

  • To identify risk factors associated with high-grade meningioma (WHO grade II/III).
  • To inform treatment decisions, surgical planning, and prognostic assessments.

Main Methods:

  • Retrospective review of 1737 patients with histologically confirmed meningioma.
  • Classification of meningiomas based on WHO 2007 grading system.
  • Analysis of tumor location using operation records and preoperative imaging.
  • Logistic regression models to determine risk factors for high-grade pathology.

Main Results:

  • Younger male patients and pediatric cases showed a higher likelihood of high-grade meningioma.
  • Meningiomas originating from non-skull base and lateral intracranial locations were more frequently high-grade (grade II/III).

Conclusions:

  • Lateral and non-skull base tumor locations are significant risk factors for WHO grade II/III meningioma.
  • Male sex and younger patient age are also associated with an increased risk of high-grade pathology.
  • These identified factors are critical for guiding treatment strategies and prognosis in meningioma patients.

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