Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Metabolism01:19

Regulation of Metabolism

Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Pharmacogenetics of Drug Metabolism: Overview01:27

Pharmacogenetics of Drug Metabolism: Overview

Genetic polymorphism in drug metabolism is crucial to the inter-individual variability observed in drug responses. Drug metabolism primarily involves the chemical modification of drugs and other xenobiotics to enhance their elimination by increasing their polarity. Two main classes of enzymes mediate this biotransformation process: Phase I enzymes, primarily cytochrome P450s, catalyze oxidation and reduction reactions, while other enzymes, such as esterases, mediate hydrolysis, and Phase II...
What is Metabolism?00:52

What is Metabolism?

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SIRT2 attenuates stress-induced skeletal muscle atrophy by inhibiting glucocorticoid receptor signalling.

bioRxiv : the preprint server for biology·2025
Same author

The Progressive Colonization of the Invasive Species <i>Amphistegina lobifera</i> on Pantelleria Island (Central Mediterranean, Sicily Channel).

Biology·2025
Same author

ZNF280A links DNA double-strand break repair to human 22q11.2 distal deletion syndrome.

Nature cell biology·2025
Same author

Derepressing nuclear pyruvate dehydrogenase induces therapeutic cancer cell reprogramming.

Cell metabolism·2025
Same author

Human Pinealectomy Syndrome and the Impact of Melatonin Replacement Therapy: 1-Cardiovascular Function.

Journal of pineal research·2025
Same author

Oxidation of retromer complex controls mitochondrial translation.

Nature·2025

Related Experiment Video

Updated: May 13, 2026

Quantitative Metabolomics of Saccharomyces Cerevisiae Using Liquid Chromatography Coupled with Tandem Mass Spectrometry
07:25

Quantitative Metabolomics of Saccharomyces Cerevisiae Using Liquid Chromatography Coupled with Tandem Mass Spectrometry

Published on: January 5, 2021

Metabolism, longevity and epigenetics.

Claudia Cosentino1, Raul Mostoslavsky

  • 1The Massachusetts General Hospital Cancer Center-Harvard Medical School, 185 Cambridge St, Boston, MA, USA.

Cellular and Molecular Life Sciences : CMLS
|March 8, 2013
PubMed
Summary
This summary is machine-generated.

Metabolic homeostasis influences lifespan by linking nutrient uptake to sirtuins and other chromatin modifiers. These proteins sense metabolic stress, driving epigenetic changes that impact longevity.

More Related Videos

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans
10:08

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans

Published on: May 18, 2022

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
10:39

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

Published on: September 17, 2020

Related Experiment Videos

Last Updated: May 13, 2026

Quantitative Metabolomics of Saccharomyces Cerevisiae Using Liquid Chromatography Coupled with Tandem Mass Spectrometry
07:25

Quantitative Metabolomics of Saccharomyces Cerevisiae Using Liquid Chromatography Coupled with Tandem Mass Spectrometry

Published on: January 5, 2021

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans
10:08

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans

Published on: May 18, 2022

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
10:39

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

Published on: September 17, 2020

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Epigenetics

Background:

  • Metabolic homeostasis and nutrient uptake influence lifespan across eukaryotes.
  • Sirtuins, NAD(+)-dependent deacetylases, sense metabolic stress and mediate adaptation.
  • Emerging evidence links other chromatin modifiers, like histone acetyltransferases, to metabolite availability.

Purpose of the Study:

  • To review the molecular mechanisms connecting metabolic stress sensing to longevity.
  • To highlight the role of sirtuins and other chromatin modifiers in metabolic adaptation.
  • To explore the crosstalk between metabolism, epigenetics, and lifespan.

Main Methods:

  • Literature review of recent studies on sirtuins, chromatin modifiers, and metabolism.
  • Synthesis of current knowledge on the interplay between metabolic state and epigenetic regulation.
  • Analysis of the functional links between metabolite availability and protein deacetylase/acetyltransferase activity.

Main Results:

  • Sirtuins act as key sensors of metabolic state, utilizing NAD(+) as a cofactor.
  • Sirtuins modulate transcription and DNA repair through epigenetic modifications.
  • Histone acetyltransferases' activity is linked to acetyl-CoA availability, suggesting broader metabolic-epigenetic crosstalk.

Conclusions:

  • Metabolic stress sensing by epigenetic machinery is crucial for adaptive responses.
  • Crosstalk between metabolic pathways and epigenetic modifiers influences cellular adaptation.
  • Understanding these links offers potential insights into longevity interventions.