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Published on: May 4, 2020
UV, stress and aging
Florence Debacq-Chainiaux1, Cedric Leduc, Alix Verbeke
1Research Unit of Cellular Biology (URBC); NARILIS; University of Namur (FUNDP); Namur, Belgium.
Abstract:
Skin is a model of choice in studies on aging. Indeed, skin aging can be modulated by internal and external factors, reflecting its complexity. Two types of skin aging have been identified: intrinsic, mainly genetically determined and extrinsic-also called "photo-aging"-resulting on the impact of environmental stress and more precisely of UV rays. Simplified in vitro models, based on cellular senescence, have been developed to study the relationship between UV and aging. These models vary on the cell type (fibroblasts or keratinocytes, normal or immortalized) and the type of UV used (UVA or UVB).
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