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Related Concept Videos

Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Components of Stress01:23

Components of Stress

Stress analysis under multiple loading conditions is intricate, necessitating a comprehensive grasp of normal and shearing stresses. Consider a small cube at point O, subjected to stress on all six faces, visible or not. Normal stress components σx, σy, σz act perpendicularly to the x, y, and z axes. Shearing stress components τxy and τxz are exerted on faces perpendicular to these axes.
Interestingly, the hidden cube faces also experience these stresses, equal and opposite to those on the...
Physiological Foundation of Stress01:24

Physiological Foundation of Stress

Stress triggers a coordinated physiological response involving the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis. This dual activation ensures that the body is prepared for both immediate and prolonged stress management. The process begins with the perception of a stressor. This initial phase activates the SNS, leading to the rapid release of adrenaline (epinephrine) from the adrenal glands.
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The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Types of Stressors01:23

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A stressor is any event, condition, or stimulus that triggers stress and causes a physical or psychological response in the body. Stressors can be categorized into three main types: catastrophes; significant life changes; and daily hassles, including social stress. Each can be detrimental to physical and mental well-being.
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Stress01:20

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When a force is applied on a body, it undergoes deformation. In order to restore the body to its original shape and/or size, an opposite or restoring force is generated within the body. This restoring force is equal to the magnitude of the applied force, but acts in the opposite direction. The amount of this restoring force developed per unit area of the body is called stress. Stress is a tensor quantity and has the SI unit pascal. Stress can be separated into four broad categories depending...

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Related Experiment Video

Updated: May 13, 2026

Assessment of Stress Effects on Cognitive Flexibility using an Operant Strategy Shifting Paradigm
07:26

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Published on: May 4, 2020

UV, stress and aging.

Florence Debacq-Chainiaux1, Cedric Leduc, Alix Verbeke

  • 1Research Unit of Cellular Biology (URBC); NARILIS; University of Namur (FUNDP); Namur, Belgium.

Dermato-Endocrinology
|March 8, 2013
PubMed
Summary

Skin aging is influenced by genetics and external factors like UV radiation. Simplified lab models using cellular senescence help study the complex relationship between UV exposure and skin aging processes.

Area of Science:

  • Dermatology and aging research.

Background:

  • Skin aging is influenced by intrinsic (genetic) and extrinsic (environmental) factors.
  • Extrinsic skin aging, or photo-aging, is primarily caused by ultraviolet (UV) radiation.
  • Cellular senescence models offer a simplified approach to studying UV-induced skin aging.

Purpose of the Study:

  • To investigate the relationship between UV radiation and skin aging.
  • To explore the utility of simplified in vitro models for aging research.

Main Methods:

  • Utilizing simplified in vitro models based on cellular senescence.
  • Employing various cell types, including fibroblasts and keratinocytes (normal or immortalized).
  • Exposing cells to different types of UV radiation (UVA or UVB).

Main Results:

Keywords:
UVBfibroblastskeratinocytessenescence

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  • In vitro models effectively simulate aspects of UV-induced skin aging.
  • Cellular senescence is a key mechanism in photo-aging.
  • Different UV types and cell models yield varied responses.

Conclusions:

  • Simplified cellular senescence models are valuable tools for understanding photo-aging.
  • Further research can refine these models for specific investigations into UV-skin interactions.