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Microarray resources for genetic and genomic studies in chicken: a review
1Department of Genetics and Genomics, The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, United Kingdom.
Genesis (New York, N.Y. : 2000)
|March 8, 2013
Summary
Microarray technology remains vital for livestock genetics and genomics research, offering affordability and high throughput. Despite next-generation sequencing (NGS) advancements, microarrays will continue to be essential tools, complementing NGS in future life science applications.
Area of Science:
- Genomics
- Livestock Genetics
Background:
- Microarray technology revolutionized genetic and genomic research by enabling massively parallel analysis of thousands of genomic sites.
- Applications include transcriptome analysis, CNV detection, genotyping, DNA-protein interaction studies, and genome methylation detection.
- Microarrays have significantly contributed to avian research, particularly in chickens as a model organism.
Purpose of the Study:
- To review microarray resources for chicken and their applications.
- To discuss the future of microarrays in the context of next-generation sequencing (NGS) and livestock genetics.
- To argue for the continued relevance of microarrays in livestock genetics and genomics.
Main Methods:
- Review of existing microarray resources for chicken.
- Discussion of past, current, and potential future applications of microarrays.
- Comparative analysis of microarrays and next-generation sequencing (NGS) technologies.
Main Results:
- Microarrays have diverse applications in genetic and genomic research, including in avian species.
- NGS technologies offer advantages like novel element discovery but face challenges.
- Microarrays are affordable, high-throughput, and established technologies crucial for livestock genetics.
Conclusions:
- Microarrays will remain essential tools in livestock genetics and genomics despite NGS advancements.
- The affordability, throughput, and established nature of microarrays ensure their continued use.
- Future research in life sciences will likely see NGS and microarrays complementing each other, especially with new technologies like capture arrays.
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