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Updated: May 13, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
2,4-Bis(2-eth-oxy-phen-yl)-3-aza-bicyclo-[3.3.1]nonan-9-one
Dong Ho Park1, V Ramkumar, P Parthiban
1Department of Biomedicinal Chemistry, Inje University, Gimhae, Gyeongnam 621 749, Republic of Korea.
Abstract:
The asymmetric unit of the title compound, C24H29NO3, contains two independent mol-ecules, which each exibit a twin-chair conformation with an equatorial orientation of the ortho-eth-oxy-phenyl groups but different dihedral angles [41.3 (1) and 24.1 (1)°] between the benzene rings. In the crystal, pairs of weak C-H⋯O hydrogen bonds link the two different independent mol-ecules into dimers.
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