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Related Experiment Videos

Increased detection of elevated TSH using immunoradiometric assay.

K Y Little1, K S Kearfott, X Castellanos

  • 1Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill.

Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie
|May 1, 1990
PubMed
Summary

A sensitive immunoradiometric assay detected more elevated thyrotropin levels in patients compared to radioimmunoassay. Most mood disorder patients with high thyrotropin showed thyroid dysfunction.

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Area of Science:

  • Endocrinology
  • Psychiatry
  • Medical Diagnostics

Background:

  • Thyroid dysfunction, particularly elevated thyrotropin (thyroid-stimulating hormone), is associated with various health conditions.
  • Accurate detection of thyrotropin is crucial for diagnosing thyroid disorders.
  • Mood disorders are sometimes linked to underlying thyroid abnormalities.

Purpose of the Study:

  • To compare the sensitivity of a highly sensitive immunoradiometric assay (IRMA) versus traditional radioimmunoassay (RIA) in detecting elevated thyrotropin.
  • To investigate the prevalence of thyroid dysfunction in patients diagnosed with mood disorders, focusing on those with elevated thyrotropin levels.

Main Methods:

  • A cohort of patients (n=2,099) was assessed using a highly sensitive immunoradiometric assay for thyrotropin.

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  • A comparative group (n=1,789) was examined using standard radioimmunoassay.
  • Patients with detected thyrotropin elevations underwent further evaluation to confirm thyroid dysfunction.

    • Main Results:

    • The immunoradiometric assay identified a higher rate of elevated thyrotropin compared to radioimmunoassay.
    • In patients with mood disorders and elevated thyrotropin, confirmatory evidence of thyroid dysfunction was found in the majority.
    • This suggests IRMA offers increased sensitivity for detecting subclinical thyroid issues.

    Conclusions:

    • Highly sensitive immunoradiometric assays provide a more accurate detection of elevated thyrotropin than radioimmunoassay.
    • Thyroid dysfunction is a significant, often undiagnosed, comorbidity in patients with mood disorders.
    • Routine screening for thyroid function in mood disorder patients may be warranted.