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Comparing apples and oranges: fold-change detection of multiple simultaneous inputs

Yuval Hart1, Avraham E Mayo, Oren Shoval

  • 1Department of Molecular Cell biology, Weizmann Institute of Science, Rehovot, Israel.

Plos One
|March 8, 2013
PubMed
Summary

Sensory systems compare multiple signals using fold-change detection. Mathematical models show responses integrate multiplicatively when signals share receptors, or via power laws if binding sites differ, enabling cells to compare diverse inputs.

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