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Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers
Published on: July 28, 2022
[Recent advances in nutritional support and postnatal growth in premature infants]
1L'Université de Liège, Belgique. Thibault.Senterre@chu.ulg.ac.be
Insights
Optimizing nutrition for very low birth weight (VLBW) infants using standardized parenteral nutrition and early enriched feeding improves growth and health. This approach reduces growth restriction, enhancing long-term development for premature infants.
Area of Science:
- Neonatology
- Pediatric Nutrition
- Intensive Care Medicine
Context:
- Premature infants, especially very low birth weight (VLBW) infants (<1500 g), face significant nutritional challenges.
- Postnatal malnutrition and growth restriction are common, impacting long-term developmental outcomes.
- Current feeding strategies often fall short in meeting the complex nutritional needs of these vulnerable infants.
Purpose:
- To discuss an optimized nutritional policy for VLBW infants.
- To highlight the benefits of standardized parenteral nutrition and accelerated enteral feeding.
- To present evidence supporting improved nutritional support and growth in premature neonates.
Summary:
- An optimized nutritional policy involving standardized parenteral nutrition and a rapidly enriched feeding regimen was implemented in VLBW infants.
- This approach led to significant improvements in nutritional support, postnatal growth, and biological homeostasis.
- A notable outcome was a reduction in infants being small for gestational age at discharge (6% vs. expected higher rates).
Impact:
- The standardized policy has been adopted by the industry, leading to the development of specialized triple-chamber parenteral nutrition bags for premature infants.
- This represents a significant advancement in improving the developmental trajectory and long-term outcomes for premature neonates.
- Enhanced nutritional strategies are crucial for mitigating the adverse effects of prematurity on infant development.
Abstract:
Nutrition has always been described as challenging in premature infants, especially in very low birth weight (VLBW, < 1500 g) infants. Therefore, postnatal malnutrition is frequently observed in these infants and most develop a severe postnatal growth restriction with a very high incidence of hypotrophy at term corrected age. Otherwise, both insufficient nutritional intakes and postnatal growth restriction during the perinatal period have been associated with adverse developmental outcomes. In this article, an optimized nutritional policy characterized by a standardization of nutritional support is discussed. This policy implies the use of one standardized parenteral nutrition solution and a rapidly enriched feeding regimen. Recent studies in VLBW infants have demonstrated that this approach is associated with significant improvement of nutritional support, postnatal growth and biological homeostasis. Only 6% of appropriate for gestational age infants at birth were described small for gestational age at discharge. This policy has recently been reproduced by the industry that developed the first manufactured triple-chamber parenteral nutrition bags specifically designed for premature infants. It represents a great opportunity for premature infants to improve their development and long-term outcomes.
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