Fetal asphyxia: a case study of translational research

Translational research is a high priority for the Canadian Institutes of Health Research and the National Institutes of Health in the United States. The history of the significance of fetal asphyxia as a cause of brain damage and cerebral palsy reflects the challenge for translational research. An antepartum and intrapartum cause of cerebral palsy was proposed in the 19th century. Our current understanding that fetal asphyxia beyond a certain threshold will cause brain damage is built on the foundation of laboratory studies conducted over the last 50 years. However, many questions remain to be answered. Clinical studies have confirmed a similar response of the human fetus to fetal asphyxia in vivo. Translation of this knowledge into patient care during the intrapartum period has been achieved to some degree. The emphasis on translational research relates to the political, public, and professional desire to improve patient care. The challenges for translational research have been highlighted in recent publications and are evident in fetal asphyxia. The goals of translational research will only be achieved with a continuing commitment to both laboratory and clinical research.