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Combined Transcranial Magnetic Stimulation and Electroencephalography of the Dorsolateral Prefrontal Cortex

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Ambient GABA responsible for age-related changes in multistable perception.

Osamu Hoshino¹

¹Department of Intelligent Systems Engineering, Ibaraki University Hitachi, Ibaraki, 316-8511, Japan. hoshino@mx.ibaraki.ac.jp

Neural Computation

|March 9, 2013

Summary

Elderly individuals experience slower perceptual switches due to age-related declines in GABA transporters. This impacts ambient GABA regulation, affecting neural network stability and multistable perception.

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Area of Science:

Neuroscience
Psychophysics
Computational Neuroscience

Background:

Multistable perception involves spontaneous alternations between interpretations of sensory input.
Younger adults exhibit more frequent perceptual switches than older adults.

Purpose of the Study:

To investigate the neural mechanisms behind age-related changes in multistable perception.
To model the impact of GABAergic system changes on perceptual switching rates.

Main Methods:

Simulated a cortical neural network model with cell assemblies.
Incorporated ambient GABA-mediated inhibition regulated by GABA transporters.
Modeled age-related decline in GABA transporter function.

Main Results:

Reduced GABA transporter function in the model slowed GABA augmentation.
This led to prolonged neural burst firing and slower perceptual switches.
The model replicated age-related differences in switching frequency.

Conclusions:

Age-related decline in GABA transporter function may underlie slower perceptual switching in the elderly.
Impaired regulation of ambient GABA levels is a potential mechanism for altered multistable perception.