Delayed onset of malignant hyperthermia in the intensive care unit: a rare but life-threatening disorder

Area of Science:

• Anesthesiology
• Genetics
• Critical Care Medicine

Background:

• Malignant hyperthermia (MH) is a rare, inherited autosomal dominant metabolic disorder.
• It is triggered by specific anesthetic agents and muscle relaxants.
• MH typically manifests in the operating room or postanesthesia care unit.

Observation:

• This case study details an atypical malignant hyperthermia crisis.
• The event occurred in an intensive care unit (ICU) setting, deviating from typical locations.
• The patient's presentation and management in the ICU are examined.

Findings:

• The study discusses the pathophysiology and genetic underpinnings of MH susceptibility.
• Diagnostic testing for MH susceptibility is reviewed.
• The critical care nurse's role in managing MH is explored.

Implications:

• This case underscores the importance of recognizing MH outside the typical perioperative environment.
• It highlights the need for critical care teams to be prepared for MH emergencies.
• Understanding MH management is crucial for potentially fatal outcomes.