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Impact of overweight and obesity on left ventricular diastolic function and value of tissue Doppler echocardiography
Antoine Kossaify1, Nayla Nicolas
1Echocardiography Unit, Cardiology Division, USEK-University Hospital ND Secours, Byblos, Lebanon.
Insights
Overweight and obesity independently impair diastolic function, a key factor in heart failure with preserved ejection fraction. This study highlights the negative impact of excess weight on heart health.
Area of Science:
- Cardiology
- Echocardiography
- Obesity Research
Background:
- Diastolic dysfunction is a frequent cause of heart failure with preserved systolic function, particularly in obese individuals.
- Obesity is increasingly recognized as a significant risk factor for cardiovascular diseases, including heart failure.
Purpose of the Study:
- To evaluate left ventricular diastolic function in overweight and obese patients.
- To utilize conventional and tissue Doppler echocardiography for assessing diastolic function in relation to body mass index (BMI) and waist circumference.
Main Methods:
- A cohort of 99 patients was studied, with BMI and waist circumference measured.
- Patients were categorized into normal weight, overweight, and obese groups based on BMI.
- Key echocardiographic parameters, including transmitral flow (E, A) and mitral annular velocities (E'), were assessed.
Main Results:
- Diastolic dysfunction was significantly more prevalent in overweight and obese groups compared to normal weight individuals.
- Multivariate regression analysis confirmed a direct and independent association between higher BMI and impaired diastolic function (OR: 2.75; P = 0.006).
- Waist circumference and other clinical factors were considered in the analysis.
Conclusions:
- Overweight and obesity exert an independent, negative influence on diastolic function.
- Tissue Doppler imaging provides a reliable method for assessing these effects.
- Findings underscore the importance of weight management in preventing diastolic heart dysfunction.
Background:
Diastolic dysfunction is a common cause of heart failure with preserved systolic function in obese patients.
Objective:
To assess diastolic function in a series of overweight and obese patients using conventional and tissue Doppler echocardiography.
Setting And Method:
University hospital; left ventricular diastolic function was evaluated in 99 patients (mean age 61.59 ± 13.9 years); body mass index and waist circumference were assessed, and patients were subdivided into three groups according to their body mass index (kg/m(2)): [normal, (18.5-24.9); overweight, (25-29.9); obese, (>29.9)]. Peak early (E) and late (A) transmitral flow and peak early (E') diastolic mitral annulus velocities were measured.
Results:
Diastolic dysfunction was significantly higher in the overweight/obese groups compared to the normal body mass index group. The analysis was made with regard to waist circumference and other clinical characteristics, and multivariate regression analysis showed a direct and independent effect of body mass index on diastolic function [OR: 2.75; CI: 1.34-5.67; P = 0.006]. Discussion was made in view of the latest clinical data. Also, an insight into normal weight obesity is presented and discussed.
Conclusion:
Overweight and obesity are found to have an independent negative impact on diastolic function as assessed by tissue Doppler imaging.
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