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Association between coronary artery ectasia and neutrophil-lymphocyte ratio
Sevket Balta1, Sait Demirkol, Turgay Celik
11Department of Cardiology, Gulhane Medical Academy, Ankara, Turkey.
Insights
Inflammation markers, like the neutrophil-lymphocyte (N/L) ratio, are linked to coronary artery ectasia (CAE). An elevated N/L ratio was observed in patients with CAE and coronary artery disease (CAD) compared to controls.
Area of Science:
- Cardiology
- Hematology
- Pathophysiology
Background:
- Atherosclerosis is a key factor in coronary artery ectasia (CAE) development.
- Inflammation markers are implicated in the pathogenesis of CAE.
Purpose of the Study:
- To investigate the association between CAE and the neutrophil-lymphocyte (N/L) ratio.
- To compare N/L ratio and mean platelet volume (MPV) in patients with CAE, coronary artery disease (CAD), and healthy controls.
Main Methods:
- A study involving 181 patients divided into three groups: CAE, newly diagnosed CAD, and normal coronary angiogram.
- Automated complete blood count to measure N/L ratio and MPV.
Main Results:
- No significant differences in N/L ratio and MPV were found between CAE and CAD groups.
- N/L ratio and MPV were significantly higher in both CAE and CAD groups compared to the control group (P < .01).
Conclusions:
- An elevated N/L ratio may contribute to the pathophysiology of CAE.
- The N/L ratio is a potential marker in the pathogenesis of both CAD and CAE.
Abstract:
Atherosclerosis plays an important role in the etiopathogenesis of coronary artery ectasia (CAE). Inflammation markers may play a part in the pathogenesis of CAE. We aimed to assess the association between the CAE and the neutrophil-lymphocyte (N/L) ratio. Consecutive eligible patients (n = 181) were divided into 3 groups: patients with CAE, those with newly diagnosed coronary artery disease (CAD), and those with a normal coronary angiogram. The N/L ratio and mean platelet volume (MPV) were measured as part of the automated complete blood count. There were no statistically significant differences in N/L ratio and MPV between the CAE and the CAD groups. The N/L ratio and MPV were significantly higher in patients in both CAE and CAD groups compared to those in the control group (P < .01). An increased N/L ratio may play a role not only in the pathogenesis of CAD but also in the pathophysiology of CAE.
