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Related Experiment Video

Updated: May 13, 2026

Polygraphic Recording Procedure for Measuring Sleep in Mice
08:45

Polygraphic Recording Procedure for Measuring Sleep in Mice

Published on: January 25, 2016

Morphine sleep in pregnancy.

A Dhanya Mackeen1, Eric Fehnel1, Vincenzo Berghella1

  • 1Department of Obstetrics and Gynecology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania.

American Journal of Perinatology
|March 9, 2013
PubMed
Summary
This summary is machine-generated.

Sixty-two percent of women admitted for labor after morphine sleep (therapeutic rest) were more likely to be admitted if they had >50% effacement and were at term. No adverse maternal or neonatal outcomes were observed.

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Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
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Published on: July 29, 2014

Area of Science:

  • Obstetrics and Gynecology
  • Maternal-Fetal Medicine
  • Pharmacology

Background:

  • Therapeutic rest, often induced with morphine sleep, is used in labor management.
  • Understanding patient characteristics and outcomes associated with therapeutic rest is crucial for clinical decision-making.

Purpose of the Study:

  • To determine the incidence of admission in labor following morphine sleep.
  • To identify patient characteristics associated with labor admission after treatment.
  • To evaluate adverse maternal and neonatal outcomes.

Main Methods:

  • Retrospective review of medical records for women receiving morphine sleep between December 2005 and December 2009.
  • Analysis of variables including medications, cervical examination, maternal demographics, obstetric history, fetal heart rate patterns, and maternal/neonatal outcomes.
  • Comparison of characteristics between women admitted in labor versus those discharged.

Main Results:

  • Of 58 women, 62% were admitted in labor, 29% were discharged, and 9% were admitted for non-reassuring fetal heart rate tracings.
  • Women with >50% effacement and term gestations were significantly more likely to be admitted in labor (p<0.01).
  • No adverse maternal outcomes were reported; neonatal outcomes showed no significant differences between groups.

Conclusions:

  • Therapeutic rest with morphine sleep resulted in labor admission for 62% of women.
  • Cervical effacement >50% and term gestational age were predictors of labor admission.
  • Morphine sleep for labor management was not associated with significant maternal or neonatal morbidity.