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Updated: May 13, 2026

High-resolution Respirometry to Measure Mitochondrial Function of Intact Beta Cells in the Presence of Natural Compounds
Published on: January 23, 2018
Metabolic and cardiovascular effects of beta cell replacement in type 1 diabetes
Piero Marchetti1, Margherita Occhipinti, Lorenzo Rondinini
1Department of Clinical and Experimental Medicine, University of Pisa, Cisanello AOUP University Hospital, Pisa, Italy. piero.marchetti@med.unipi.it
Abstract:
Type 1 diabetes is associated with high morbidity and mortality, mostly due to the acute and chronic complications of the disease. Restoration of the lost beta cell mass by pancreas transplantation is the treatment of choice in selected type 1 diabetic patients. Growing data show that successful pancreas transplantation normalizes the metabolic alterations of diabetes, and can slow the progression, stabilize, and even favor the regression of secondary complications of the disease, including those at the cardiovascular level.
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