Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...
Liver Physiology01:30

Liver Physiology

The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can also...
Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
Hepatic Encephalopathy01:29

Hepatic Encephalopathy

DefinitionHepatic encephalopathy is a reversible neurologic syndrome that results from advanced liver dysfunction or portosystemic shunting. It leads to disturbances in cognition, behavior, and motor function due to the brain’s exposure to gut-derived toxins that the liver fails to detoxify.EtiologyThis condition develops either in the setting of acute fulminant hepatitis or progressively during chronic liver disease, such as cirrhosis and portal hypertension. Portosystemic shunting—including...
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug binding...
Esophageal Varices-II: Clinical Features and Management01:28

Esophageal Varices-II: Clinical Features and Management

Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol abuse, or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Blood Pressure Variability in Acute Ischemic Stroke: Current Evidence, Measurement Challenges, and Future Directions.

Journal of clinical hypertension (Greenwich, Conn.)·2026
Same author

Right Upper Lobe Pulmonary Spindle Cell Neoplasm With Rhabdoid Differentiation and Spinal Canal Invasion in a 19-Year-Old Female: A Case Report.

Clinical case reports·2026
Same author

Retraction notice to 'Hydrogeochemical properties, source provenance, distribution, and health risk of high fluoride groundwater: Geochemical control, and source apportionment' [Environ. Pollut. 362, (2024) 125000].

Environmental pollution (Barking, Essex : 1987)·2026
Same author

Interface and Surface Chemistry Engineering in HgTe Quantum Dots for High-Performance Infrared Optoelectronic Devices.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Autism spectrum disorder trios from consanguineous populations are enriched for rare homozygous variants, identifying 32 new candidate genes.

Scientific reports·2026
Same author

Highly sensitive electrochemical detection and quantification of opium derived morphine sulfate using cysteamine loaded MWCNTs@V<sub>2</sub>O<sub>5</sub> telluride composite.

Scientific reports·2026

Related Experiment Video

Updated: May 13, 2026

A Plate-based Cytotoxicity Assay for the Assessment of Rat Placental Natural Killer Cell Cytolytic Function
10:44

A Plate-based Cytotoxicity Assay for the Assessment of Rat Placental Natural Killer Cell Cytolytic Function

Published on: June 2, 2019

Liver function tests in preeclampsia.

Bibi Munazza1, Nuzhat Raza, Ayesha Naureen

  • 1Department of Physiology, Ayub Medical College, Abbottabad, Pakistan. drmunazzaqasim@gmail.com

Journal of Ayub Medical College, Abbottabad : JAMC
|March 12, 2013
PubMed
Summary
This summary is machine-generated.

Preeclampsia significantly elevates liver enzymes and serum bilirubin compared to normal pregnancy. This study highlights key liver function test differences in preeclampsia, crucial for understanding its systemic impact.

More Related Videos

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
12:17

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

Published on: August 2, 2017

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas
05:31

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas

Published on: January 26, 2024

Related Experiment Videos

Last Updated: May 13, 2026

A Plate-based Cytotoxicity Assay for the Assessment of Rat Placental Natural Killer Cell Cytolytic Function
10:44

A Plate-based Cytotoxicity Assay for the Assessment of Rat Placental Natural Killer Cell Cytolytic Function

Published on: June 2, 2019

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
12:17

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

Published on: August 2, 2017

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas
05:31

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas

Published on: January 26, 2024

Area of Science:

  • Obstetrics and Gynecology
  • Hepatology
  • Clinical Biochemistry

Background:

  • Preeclampsia is a serious pregnancy complication affecting multiple organ systems, including the liver.
  • Pregnancy-induced hypertension (PIH) contributes significantly to maternal and perinatal morbidity.
  • Understanding liver function alterations in preeclampsia is vital for patient management.

Purpose of the Study:

  • To compare liver function tests in women with preeclampsia versus those with normal pregnancies.
  • To identify specific biochemical markers indicative of liver involvement in preeclampsia.

Main Methods:

  • A comparative study involving 100 pregnant women (50 preeclampsia, 50 normal pregnancy) after 20 weeks gestation.
  • Inclusion criteria for preeclampsia: blood pressure ≥ 140/90 mmHg, proteinuria ≥ 300 mg/24h, and edema.
  • Measurement of serum bilirubin and plasma levels of ALT, AST, and ALK in both groups.

Main Results:

  • Preeclamptic women showed significantly higher mean serum bilirubin (10.78 vs 7.92 µmol/L, p < 0.001).
  • Elevated mean liver enzyme levels were observed in preeclampsia: ALT (55.81 vs 15.22 U/L, p < 0.001), AST (41.34 vs 24 U/L, p < 0.001), and ALK (454.16 vs 181.34 U/L, p < 0.001).
  • Mean BMI was also higher in the preeclampsia group (29.04 vs 26.54).

Conclusions:

  • Preeclampsia is associated with significantly elevated serum bilirubin and liver enzymes (ALT, AST, ALK).
  • These findings underscore the hepatic impact of preeclampsia and the utility of liver function tests in its diagnosis and monitoring.