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Updated: May 13, 2026

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans
Published on: November 26, 2017
Analysis of protein aggregation in neurodegenerative disease
Jeppe T Pedersen1, Niels H H Heegaard
1Department of Chemistry, Faculty of Science, University of Copenhagen, Copenhagen Ø, Denmark.
Abstract:
Pathological protein and peptide aggregation are key events in a number of chronic and devastating neurodegenerative conditions including dementias such as Alzheimer's and Creutzfeldt-Jakob's disease and other central nervous system diseases such as Parkinson's and Huntington's disease and amyotrophic lateral sclerosis. Analytical methods for studying protein aggregation in these diseases are important for mapping pathophysiological events and ultimately for the development of new therapies and better diagnostic tools.
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