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Updated: May 13, 2026
Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-Like Cells using the Three-Dimensional Co-Culture System, NICO-1
Published on: December 5, 2020
Elevated VEGF concentrations in ascites and serum predict adverse prognosis in ovarian cancer
Bin Liang1, Zhengdong Guo1, Yunhui Li2
1a High Vocational Technological College, China Medical University , Shenyang.
Objective:
To evaluate if serum and ascites VEGF-C concentration could be used as prognostic markers in ovarian cancer.
Materials And Methods:
Serum and ascites VEGF-C were measured in 118 patients with ovarian cancer and 24 patients with benign gynaecological disease. ELISA method was employed to evaluate VEGF-C concentration.
Results:
Serum and ascites in ovarian cancer patients were higher than those in benign gynaecological disease (P < 0.0001). Serum VEGF-C and ascites VEGF-C were both correlated with FIGO stage, tumor grade, and lymph node metastasis (P < 0.05). Univariate analysis revealed that FIGO stage (P < 0.0001), tumor grade (P < 0.0001), lymph node metastasis (P < 0.0001), serum VEGF-C concentration (P = 0.0001), and ascites VEGF-C concentration (P < 0.0001) were significantly correlated with overall survival. Including these variables in a multivariate analysis revealed that VEGF-C concentrations in serum and ascites were independent predictors of shorter overall survival.
Conclusion:
Elevated VEGF-C concentrations in serum and ascites can be seen as the novel, widely available independent predictors of shorter overall survival in ovarian cancer.
