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Updated: May 13, 2026

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease

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Published on: March 17, 2020

Post-bone-marrow-transplant leukemia cutis.

Fernando Pulgar¹, Dolores Vélez, Nuria Valdeolivas

¹Hospital Universitario Príncipe de Asturias, Madrid, Spain.

Dermatology Online Journal

|March 12, 2013

Summary

Granulocytic sarcoma, a rare acute myeloid leukemia complication, typically affects the skin. This case highlights a unique post-transplant relapse with cutaneous involvement, despite no prior extramedullary disease.

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Area of Science:

Hematology
Oncology
Dermatology

Background:

Granulocytic sarcoma (chloroma) involves immature granulocytes, often linked to acute myeloid leukemia (AML).
Skin is a frequent site for granulocytic sarcoma, and its presence can indicate a poor prognosis in hematological disorders.

Observation:

A 51-year-old patient with AML and complex karyotype presented with a rare post-transplant relapse.
The relapse manifested as cutaneous and hematological involvement.

Findings:

This case is unusual as the patient had no prior extramedullary disease before the transplant.
The recurrence involved skin and hematological systems, a rare presentation post-hematopoietic stem cell transplantation.

Implications:

This case underscores the possibility of rare relapse patterns in AML patients post-transplant.
Understanding such unique presentations is crucial for refining treatment strategies and prognostic assessments in relapsed AML.