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Related Experiment Video

Updated: May 13, 2026

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Published on: April 14, 2016

Treating acetaminophen overdose: thresholds, costs and uncertainties.

S Gosselin¹, R S Hoffman, D N Juurlink

¹Centre Antipoison du Québec, McGill University Health Centre, Montréal, QC, Canada. sophie.gosselin@mcgill.ca

Clinical Toxicology (Philadelphia, Pa.)

|March 12, 2013

Summary

The UK lowered the acetaminophen overdose treatment threshold, potentially increasing costs without clear patient benefit. Cost-effectiveness analysis is needed before adopting new N-acetylcysteine guidelines.

Related Experiment Videos

Last Updated: May 13, 2026

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Published on: April 14, 2016

Area of Science:

Pharmacology
Toxicology
Public Health Policy

Background:

Acetaminophen (paracetamol) overdose is a common cause of acute liver injury.
N-acetylcysteine is the standard antidote for acetaminophen toxicity.
The UK's MHRA updated treatment guidelines in 2012.

Purpose of the Study:

To evaluate the implications of the MHRA's revised acetaminophen overdose treatment threshold.
To assess the potential cost-effectiveness of the new N-acetylcysteine therapy guidelines.

Main Methods:

Analysis of the MHRA's 2012 guideline change regarding acetaminophen concentration thresholds.
Review of potential impacts on hospital admissions and treatment costs.
Discussion of the need for cost-effectiveness studies.

Main Results:

The treatment threshold for acetaminophen concentration was lowered from 200 mg/L to 100 mg/L at 4 hours post-ingestion.
This change may lead to increased hospital referrals and N-acetylcysteine treatments.
The clinical benefit of protecting a marginal increase in patients is unclear.

Conclusions:

The revised UK guideline for acetaminophen overdose may increase healthcare costs.
Further cost-effectiveness analyses are crucial to justify the new treatment thresholds.
Evidence-based thresholds are needed to optimize patient care and resource allocation.