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Related Concept Videos

Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).

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Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
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Brain connectivity in body dysmorphic disorder compared with controls: a diffusion tensor imaging study.

B G Buchanan1, S L Rossell, J J Maller

  • 1Monash Alfred Psychiatry Research Centre, School of Psychology and Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University and The Alfred Hospital, Melbourne, Australia.

Psychological Medicine
|March 12, 2013
PubMed
Summary
This summary is machine-generated.

Body dysmorphic disorder (BDD) patients exhibit significantly reduced white matter connectivity, indicated by lower fractional anisotropy (FA) in major brain tracts. This finding suggests inefficient neural connections may underlie BDD symptoms.

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Related Experiment Videos

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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
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Area of Science:

  • Neuroimaging
  • Psychiatry
  • White Matter Integrity

Background:

  • Previous studies noted grey matter abnormalities in body dysmorphic disorder (BDD).
  • This research investigates white matter properties in BDD using diffusion tensor imaging (DTI).

Purpose of the Study:

  • To compare white matter connectivity in BDD patients versus healthy controls.
  • To test the hypothesis of widespread reduced white matter connectivity in BDD.

Main Methods:

  • Diffusion tensor imaging (DTI) was performed on 20 BDD patients and 20 matched healthy controls.
  • Voxel-wise comparison of fractional anisotropy (FA) was conducted using tract-based spatial statistics.

Main Results:

  • BDD patients showed significantly lower FA in major white matter tracts compared to controls.
  • Reduced FA was associated with increased radial diffusivity.
  • No areas of higher FA were observed in BDD patients.

Conclusions:

  • This study presents the first evidence of compromised white matter integrity in BDD.
  • Inefficient brain connectivity may contribute to cognitive and emotion regulation deficits in BDD.