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Relation between mean platelet volume and coronary collateral vessels in patients with acute coronary syndromes

Mustafa Duran1, Ozgur Gunebakmaz, Onur Kadir Uysal

  • 1Kayseri Research and Education Hospital, Kayseri, Turkey. mduran2@gmail.com

Journal of Cardiology
|March 12, 2013
PubMed

Insights

High mean platelet volume (MPV) is linked to the presence of coronary collateral vessels (CCV) in patients experiencing acute coronary syndrome (ACS). This finding suggests MPV may indicate better collateralization in ACS patients.

Area of Science:

  • Cardiology
  • Hematology
  • Vascular Biology

Background:

  • Elevated mean platelet volume (MPV) is a potential risk factor for coronary artery disease (CAD).
  • MPV is associated with adverse clinical outcomes in patients with acute coronary syndrome (ACS).

Purpose of the Study:

  • To investigate the association between MPV and the development of coronary collateral vessels (CCV) in patients with ACS.

Main Methods:

  • A cohort of 417 ACS patients undergoing coronary angiography was analyzed.
  • Coronary collateral vessels were assessed using the Rentrop scoring system.
  • Patients were categorized into groups based on the presence (Rentrop grade 1-3) or absence (Rentrop grade 0) of CCVs.

Main Results:

  • The presence of CCVs was significantly associated with higher MPV levels (p=0.005).
  • Higher MPV was also correlated with diabetes and systolic blood pressure.
  • The study included 233 patients without CCVs and 184 patients with CCVs.

Conclusions:

  • Elevated MPV on admission is associated with the presence of CCVs in patients with ACS.
  • MPV may serve as a potential indicator for coronary collateralization in ACS.
Abstract

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