Related Experiment Video
Updated: May 13, 2026
Fixation and Operational Method for Abdominal Massage in T2DM Mice
Published on: March 7, 2025
Effect of vitamin E on alloxan-induced mouse diabetes
Wakana Kamimura1, Wakana Doi, Kazunori Takemoto
1Department of Life Science, Okayama University of Science, 1-1 Ridai-cho, Kita-ku, Okayama 700-0005, Japan.
Objectives:
Alloxan generates hydrogen peroxide in the body, and a small amount of alloxan administered to acatalasemic mice results in diabetes. D-α-Tocopherol (vitamin E) is an antioxidant which helps prevent excess oxidation in the body. In this study, we examined the effect of vitamin E on diabetes caused by alloxan administration in mice.
Methods:
Mice were maintained on a vitamin E-deprived diet and supplemented diet, respectively, for 14 weeks. Alloxan was then intraperitoneally administered, and blood glucose, glucose tolerance and the insulin level in mouse blood were examined.
Results:
Hyperglycemia was observed in the mice maintained on the vitamin E-deprived diet. The incidence of hyperglycemia in the mice maintained on the vitamin E-deprived diet was significantly higher than that in the mice maintained on the supplemented diet. The abnormal glucose metabolism caused by alloxan administration was ameliorated by the vitamin E-supplemented diet.
Conclusions:
It is deduced that vitamin E can prevent a decrease of insulin concentration in the blood in this mouse model.
