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Updated: May 13, 2026

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Published on: September 21, 2017

Bioinspired peptides as versatile nucleic acid delivery platforms.

¹CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad-500007, Andhra Pradesh, India. vijaya@ccmb.res.in

Journal of Controlled Release : Official Journal of the Controlled Release Society

|March 12, 2013

Summary

Cell-penetrating peptides (CPPs) are versatile tools in non-viral gene therapy, enabling targeted delivery of nucleic acids. This review explores CPPs, including TAT-PTD, for cancer therapy and plant biotechnology.

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Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures

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Published on: June 26, 2020

Area of Science:

Biotechnology
Molecular Biology
Nanotechnology

Background:

Non-viral gene therapy increasingly utilizes peptides for efficient cellular delivery of therapeutic molecules.
Cell-penetrating peptides (CPPs) are short peptide sequences and derivatives that facilitate intracellular delivery.
CPPs can be engineered with ligands for cell-specific targeting of nucleic acids.

Purpose of the Study:

To review the structural requirements and applications of cell-penetrating peptides (CPPs) in gene therapy.
To highlight the role of CPPs, such as TAT-PTD, in nanotechnology-based cancer therapy.
To discuss the potential of CPPs in plant biotechnology.

Main Methods:

Literature review focusing on CPPs and their derivatives.
Analysis of structural features of CPPs like TAT-PTD.
Exploration of recent advancements in CPP applications for cancer therapy and plant biotechnology.

Main Results:

CPPs are integral to non-viral gene delivery platforms, enhancing therapeutic molecule transfer.
Engineered CPPs with specific ligands enable targeted nucleic acid delivery in vitro and in vivo.
The review details CPPs' utility in cancer nanomedicine and their biotechnological potential in plants.

Conclusions:

Cell-penetrating peptides offer versatile solutions for gene therapy and targeted drug delivery.
Structural modifications of CPPs, like TAT-PTD, are crucial for their efficacy in gene therapy and cancer treatment.
CPPs hold significant promise for future applications in plant biotechnology.