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Updated: May 13, 2026
07:17
Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
Published on: June 22, 2016
[Regulatory T cells in chronic obstructive pulmonary disease]
Leonardo Limón-Camacho1, Helena Solleiro-Villavicencio, Ilana Pupko-Sissa
1Unidad de Posgrado, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), México, D.F., México.
Archivos De Cardiologia De Mexico
|March 12, 2013
Summary
Regulatory T cells (Treg) are crucial for immune balance. Disrupted Treg function contributes to the inflammation seen in chronic obstructive pulmonary disease (COPD).
Area of Science:
- Immunology
- Pulmonology
Background:
- Tobacco smoke is the primary risk factor for COPD, causing airway inflammation.
- Inflammatory responses are maladaptively modulated in COPD pathogenesis.
- Regulatory T cells (Treg) are T CD4(+) lymphocytes that modulate immune responses via cytokine secretion.
Purpose of the Study:
- To systematically review the literature on Treg cells, including their ontogeny and mechanisms of action.
- To elucidate the role of Treg cells in the pathogenesis of chronic obstructive pulmonary disease (COPD).
Main Methods:
- Systematic literature search of MEDLINE, AMED, PubMed, and Scielo databases.
- Keywords included "COPD and Regulatory T cells", "Inflammation and COPD", and "Regulatory T cells".
- Inclusion of basic science articles, clinical trials, meta-analyses, and guides.
Main Results:
- Treg cells are T CD4(+) lymphocytes.
- Key functions include immune response suppression and self-antigen tolerance maintenance.
- Disruption of Treg regulatory mechanisms contributes to COPD inflammation.
Conclusions:
- Treg cells play a significant role in immune regulation.
- Dysfunctional Treg cells are implicated in the development and persistence of inflammation in COPD.
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