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The short- and long-term effect of single high-dose intra-operative electron beam irradiation of retroperitoneal
H J Hoekstra1, D M Mehta, J W Oosterhuis
1Division of Surgical Oncology, Gronigen University Hospital, The Netherlands.
Abstract:
Intra-operative electron beam radiotherapy is a new treatment modality. The abdomen is the area of greatest potential applicability of IORT and therefore its effect on retroperitoneal structures was investigated in a canine model. The retroperitoneal structures tolerate 30 to 40 Gy well, with the exception of the radiation-sensitive ureter which showed fibrosis. Twenty to 25 Gy is within the safe dose limits for the clinical application of IORT.