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Shell crosslinked knedel-like nanoparticles for delivery of cisplatin: effects of crosslinking
Fuwu Zhang1, Mahmoud Elsabahy, Shiyi Zhang
1Department of Chemistry, Laboratory for Synthetic - Biologic Interactions, Texas A&M University, P.O. Box 30012, 3255 TAMU, College Station, Texas 77842-3012, USA.
Nanoscale
|March 12, 2013
Abstract:
Polymeric micelles and shell crosslinked knedel-like (SCK) nanoparticles were loaded with up to 48% (w/w) cisplatin. These spherical cisplatin-loaded nanoparticles displayed sustained platinum release over 5 days in PBS, enhanced stability over free cisplatin in aqueous milieu, and significant antitumor activity in vitro against two cancer cell lines.

