Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Hypersensitivity Reactions: Immune-Complex Reactions

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...

Drug Toxicity: Allergic Reactions

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...

Allergic Drug Reactions

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...

Hypersensitivity Reactions: Delayed Hypersensitivity Reactions

Hypersensitivity Reactions: Delayed Hypersensitivity Reactions

Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...

Rheumatic Heart Disease I: Introduction

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...

Rh Blood Group

Rh Blood Group

The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Isolated perianal hypertrophic lichen planus in men.

Clinical and experimental dermatology·2026

Same author

Genital Disorders in Children: What Does a Biopsy Bring?

Dermatopathology (Basel, Switzerland)·2026

Same author

Longitudinal Melanonychia in Children: Clinical and Histopathologic Features and Management with Literature Update.

Dermatopathology (Basel, Switzerland)·2026

Same author

Isolated multiple minute digitate keratoses of the penile shaft in an adult.

Clinical and experimental dermatology·2026

Same author

Primary Sweat Gland Adenocarcinoma of the Skin With ATL2::PRKD3 Fusion: A Potential Cutaneous Analog of Cribriform Adenocarcinoma of the Salivary Glands?

Genes, chromosomes & cancer·2025

Same author

Lichen aureus of the penile shaft in adults.

Clinical and experimental dermatology·2025

Search research articles

Related Experiment Video

Updated: May 13, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Foreign body reaction to Radiesse: 2 cases.

Isabelle Moulonguet¹, Eric Arnaud, Patrick Bui

¹Cabinet de Dermatopathologie, Paris, France. imoulonguetmichau@gmail.com

The American Journal of Dermatopathology

|March 12, 2013

Summary

Foreign body reactions to Radiesse, a calcium hydroxylapatite filler, can occur. Histopathology reveals distinctive inflammatory changes and filler material, even in unexpected sites.

Related Experiment Videos

Last Updated: May 13, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Area of Science:

Dermatopathology
Plastic Surgery
Biomaterials Science

Background:

Radiesse is a semipermanent soft-tissue filler composed of calcium hydroxylapatite microspheres in a carboxymethyl cellulose gel carrier.
While often considered non-immunogenic, adverse reactions to dermal fillers are possible.
Understanding filler-tissue interactions is crucial for patient safety and treatment outcomes.

Observation:

Two cases of foreign body reaction to Radiesse injections are presented.
One case manifested as a columellar nodule discovered during rhinoplasty.
The second case was identified during histopathologic examination of a basal-cell carcinoma specimen.

Findings:

Histopathology revealed a foreign body reaction characterized by giant cells, histiocytes, plasma cells, and lymphocytes.
Distinctive, nonpolarizing, yellowish, extracellular deposits consistent with Radiesse filler were identified.
These findings challenge the notion that Radiesse does not induce foreign body reactions, with similar histopathologic patterns noted in prior studies.

Implications:

The distinctive histopathologic appearance of Radiesse reactions is readily recognizable by dermatologists and dermatopathologists.
These findings highlight the importance of considering filler material in the differential diagnosis of nodules and inflammatory reactions.
Further research may elucidate the precise mechanisms and prevalence of foreign body reactions to calcium hydroxylapatite fillers.