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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Allergic Reactions02:06

Allergic Reactions

Overview

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Related Experiment Video

Updated: May 13, 2026

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Virus/allergen interactions in asthma.

Monica L Gavala1, Hiba Bashir, James E Gern

  • 1Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706, USA. mgavala@medicine.wisc.edu

Current Allergy and Asthma Reports
|March 12, 2013
PubMed
Summary

Allergies and viral infections worsen asthma by creating interactive inflammatory pathways. Understanding these virus-allergen interactions offers new therapeutic targets for allergic asthma treatment and prevention.

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Murine Model of Allergen Induced Asthma
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Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
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Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
11:54

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Published on: January 21, 2018

Area of Science:

  • Immunology
  • Respiratory Medicine
  • Pathophysiology

Background:

  • Asthma is a significant clinical concern, frequently exacerbated by allergies and viral respiratory infections.
  • Emerging evidence suggests interactive inflammatory mechanisms between viruses and allergens contribute to asthma development and severity.

Purpose of the Study:

  • To elucidate the molecular mechanisms underlying virus-allergen cross-talk in allergic asthma.
  • To identify potential therapeutic targets for managing allergic asthma and preventing exacerbations.

Main Methods:

  • Review of recent scientific literature on virus-allergen interactions in asthma.
  • Analysis of key immunological and cellular pathways involved in allergic asthma pathophysiology.

Main Results:

  • Identified five key mechanisms of virus-allergen cross-talk: impaired interferon responses, compromised epithelial barrier function, elevated pro-inflammatory cytokines (TSLP, IL-25, IL-33), lymphocyte dysregulation (ILCs, Tregs), and altered purinergic receptor activity.
  • These mechanisms highlight complex inflammatory interactions driving allergic asthma.

Conclusions:

  • Virus-allergen interactions represent critical pathways in allergic asthma.
  • Targeting these specific mechanisms, such as interferon responses or cytokine signaling, may lead to novel treatments for allergic asthma.