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Related Experiment Video

Updated: May 13, 2026

Methods to Explore the Influence of Top-down Visual Processes on Motor Behavior
09:49

Methods to Explore the Influence of Top-down Visual Processes on Motor Behavior

Published on: April 16, 2014

ProFit revisited.

Alexander Fuchs1, Peter Boesiger, Rolf F Schulte

  • 1Department of Information Technology and Electrical Engineering, Institute for Biomedical Engineering, ETH & University Zurich, Switzerland.

Magnetic Resonance in Medicine
|March 12, 2013
PubMed
Summary
This summary is machine-generated.

An improved ProFit tool enhances quantification of 2D J-resolved spectroscopy (JPRESS) data. This allows for reliable detection of numerous brain metabolites using 3T magnetic resonance imaging.

Related Experiment Videos

Last Updated: May 13, 2026

Methods to Explore the Influence of Top-down Visual Processes on Motor Behavior
09:49

Methods to Explore the Influence of Top-down Visual Processes on Motor Behavior

Published on: April 16, 2014

Area of Science:

  • Magnetic Resonance Spectroscopy
  • Metabolomics
  • Neuroimaging

Background:

  • Quantitative analysis of magnetic resonance spectroscopy (MRS) data is crucial for understanding brain metabolism.
  • Existing fitting tools may have limitations in accurately quantifying complex spectral data, particularly for 2D J-resolved spectroscopy (JPRESS).

Purpose of the Study:

  • To develop and validate an enhanced version of the ProFit fitting tool.
  • To improve the accuracy and reliability of metabolite quantification from 2D JPRESS data.

Main Methods:

  • Incorporated flexible prior knowledge organization and situation-specific configurations.
  • Included measured macromolecular baseline contribution and additional baseline splines.
  • Utilized a model-free lineshape based on self-deconvolution for enhanced fitting.
  • Tested and tuned the software on simulated and in vivo intrasubject/intersubject data.

Main Results:

  • The enhanced ProFit tool demonstrated good overall fit quality for both simulated and acquired spectra.
  • Achieved reliable detection of up to 18 metabolites on a 3T system.
  • Reported Cramer-Lower-Bounds below 20% for metabolite quantification.

Conclusions:

  • The enhanced ProFit software, combined with 2D JPRESS, provides a robust method for metabolite quantification.
  • Offers the potential for reliable detection of a wide range of essential brain metabolites at 3T.
  • Facilitates advancements in neurochemical research and clinical applications.