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Updated: May 13, 2026

Quantification of Hypopigmentation Activity In Vitro
Published on: March 6, 2019
Azastilbene analogs as tyrosinase inhibitors: new molecules with depigmenting potential
Larissa Lavorato Lima1, Rebeca Mól Lima, Annelisa Farah da Silva
1Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Juiz de Fora, Campus Universitário, 36036-900 Juiz de Fora, MG, Brazil.
Abstract:
This research has been an effort to develop synthetic resveratrol analogs in order to improve the depigmenting potential of natural resveratrol. Six resveratrol analogs were synthesized and tested for tyrosinase inhibitory activity in vitro, by qualitative and quantitative steps. The results showed the analog C as being the most powerful tyrosinase inhibitor (IA50=65.67±0.60 μg/mL), followed by the analogs B, E, F, A, and D, respectively. The analog C presented a tyrosinase inhibition potential better than natural resveratrol (P<0.001). The best depigmenting activity was provided by the presence of hydroxyl in the orthoposition on the second phenolic ring.
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