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Updated: May 13, 2026

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
3-Hy-droxy-2-meth-oxy-benzamide
Sabine Wilbrand1, Christian Neis, Kaspar Hegetschweiler
1Fachrichtung Chemie, Universität des Saarlandes, Postfach 151150, D-66041 Saarbrücken, Germany.
Abstract:
The crystal structure of the title compound, C8H9NO3, features centrosymmetric dimers with two amide groups inter-connected by a pair of almost linear N-H⋯O hydrogen bonds. Through inter-molecular O-H⋯O inter-actions between phenolic hy-droxy groups and carbonyl O atoms, these dimers are assembled into undulating hydrogen-bonded layers parallel to the [101] plane. Additionally, the anti-H(-N) atom of the primary amide group forms an intra-molecular hydrogen bond to the O atom of the meth-oxy group. The amide group froms a dihedral angle of 12.6 (1)° with the phenyl ring.
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