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Related Experiment Video

Updated: May 13, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives

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Published on: February 15, 2016

7-[(Morpholin-4-yl)(phen-yl)meth-yl]quinolin-8-ol.

J Josephine Novina¹, G Vasuki, C Muthukumar

¹Department of Physics, Idhaya College for Women, Kumbakonam-1, India.

Acta Crystallographica. Section E, Structure Reports Online

|March 12, 2013

Summary

This study details the crystal structure of a C20H20N2O2 compound, revealing specific dihedral angles between its quinoline, benzene, and morpholine rings. Molecular pairs are linked by hydrogen bonds, forming characteristic R2(2)(10) motifs in the crystal lattice.

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Area of Science:

Crystallography
Organic Chemistry
Molecular Structure

Background:

Understanding the three-dimensional arrangement of atoms in organic molecules is crucial for predicting their properties and reactivity.
The quinoline scaffold is a prevalent motif in medicinal chemistry and materials science.

Purpose of the Study:

To elucidate the detailed crystal structure of the title compound (C20H20N2O2).
To quantify the spatial relationships between the constituent ring systems (quinoline, benzene, morpholine).
To identify and characterize intermolecular interactions within the crystal lattice.

Main Methods:

Single-crystal X-ray diffraction was employed to determine the molecular and crystal structure.
Geometric analyses were performed to calculate dihedral angles between the ring planes.
Analysis of intermolecular interactions, specifically hydrogen bonding, was conducted.

Main Results:

The quinoline ring system exhibits dihedral angles of 81.05(4)° and 61.16(5)° with the benzene and morpholine rings, respectively.
A significant dihedral angle of 83.59(4)° was observed between the benzene and morpholine rings.
Pairs of molecules are interconnected via O-H⋯N hydrogen bonds, forming R2(2)(10) motifs through twofold rotation.

Conclusions:

The crystal structure of C20H20N2O2 reveals a specific non-planar conformation with defined inter-ring angles.
The identified hydrogen bonding network plays a significant role in the supramolecular assembly of the compound in the solid state.
These structural insights contribute to the understanding of quinoline derivatives and their packing in crystals.