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6-Phenyl-oxane-2,4-dione.

Kara A Slater1, Brad Andersh, Edward B Flint

  • 1Mund-Lagowski Department of Chemistry & Biochemistry, Bradley University, Peoria, IL 61625, USA ; Department of Chemistry, University of Iowa, Iowa City, IA 52242, USA.

Acta Crystallographica. Section E, Structure Reports Online
|March 12, 2013
PubMed
Summary
This summary is machine-generated.

This study details a phenyl-substituted dihydro-pyran-dione molecule. Its heterocyclic ring adopts a boat conformation, with the phenyl group positioned at a specific angle relative to the ring.

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Area of Science:

  • Organic Chemistry
  • Crystallography

Background:

  • Dihydro-pyran-dione derivatives are important scaffolds in medicinal chemistry.
  • Understanding the conformational preferences of such molecules is crucial for predicting their biological activity.

Purpose of the Study:

  • To characterize the three-dimensional structure of a novel phenyl-substituted dihydro-pyran-dione.
  • To analyze the conformational behavior of the heterocyclic ring and the orientation of the phenyl substituent.

Main Methods:

  • Single-crystal X-ray diffraction analysis was employed to determine the molecular structure.
  • The conformation of the heterocycle and the dihedral angle of the phenyl substituent were analyzed.

Main Results:

  • The title compound, C11H10O3, was successfully synthesized and characterized.
  • The dihydro-pyran-dione heterocycle adopts a boat conformation.
  • The phenyl substituent is canted at 72.14(5)° relative to the mean plane of the heterocycle.

Conclusions:

  • The study provides precise structural data for a phenyl-substituted dihydro-pyran-dione.
  • The observed boat conformation and phenyl group orientation offer insights into the molecule's stereochemistry and potential interactions.