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Updated: May 13, 2026

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
2-(4-Acetamido-phen-oxy)-2-methyl-propanoic acid
Gabriel Navarrete-Vázquez1, Blanca Colín-Lozano, Hugo Tlahuext
1Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001 Col., Chamilapa, CP 62100, Cuernavaca Mor., Mexico.
This study analyzes the crystal structure of a novel organic compound, C12H15NO4. Molecular analysis reveals specific dihedral angles and hydrogen bonding patterns that form corrugated sheets in the crystal lattice.
Area of Science:
- Crystallography
- Organic Chemistry
- Materials Science
Background:
- Understanding molecular interactions is crucial for designing new materials.
- Crystal structure analysis provides insights into intermolecular forces.
Purpose of the Study:
- To determine the crystal structure of the compound C12H15NO4.
- To investigate the intermolecular interactions and packing in the crystal.
Main Methods:
- Single-crystal X-ray diffraction was employed to analyze the crystal structure.
- Analysis of hydrogen bonding and graph-set motifs was performed.
Main Results:
- The dihedral angle between the acetamide group and the ring was determined to be 29.6(2)°.
- Molecules are linked via N-H⋯O and O-H⋯O hydrogen bonds, forming corrugated sheets.
- These sheets exhibit R4(4)(28) graph-set motifs.
Conclusions:
- The crystal structure of C12H15NO4 is characterized by specific dihedral angles and extensive hydrogen bonding.
- The observed hydrogen bonding network leads to the formation of corrugated sheets, influencing the material's properties.
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