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Related Experiment Video

Updated: May 13, 2026

Mouse In Vivo Placental Targeted CRISPR Manipulation

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Published on: April 14, 2023

Expression and Function of PPARs in Placenta.

Satoru Matsuda¹, Mayumi Kobayashi, Yasuko Kitagishi

¹Department of Environmental Health Science, Nara Women's University, Kita-Uoya Nishimachi, Nara 630-8506, Japan.

|March 12, 2013

Summary

Peroxisome proliferator-activated receptors (PPARs) regulate gene expression in embryonic development, particularly in the placenta. These nuclear receptors translate nutritional signals into developmental pathways, influencing lipid homeostasis and tissue differentiation.

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Area of Science:

Endocrinology
Molecular Biology
Developmental Biology

Background:

Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors crucial for embryonic development and tissue differentiation.
PPARs respond to ligands like polyunsaturated fatty acids, modulating gene expression and lipid homeostasis.

Purpose of the Study:

To elucidate the role of PPARs in placental development and gene expression regulation.
To understand how PPARs translate nutritional stimuli into developmental pathways.

Main Methods:

Review of existing literature on PPARs and nuclear hormone receptors.
Analysis of PPARs' interaction with ligands and other transcription factors (e.g., RXRs).

Main Results:

PPARs are involved in the differentiation of various tissues, including the placenta.
PPARs coordinate gene expression with RXRs and are subject to negative regulatory mechanisms.
PPARs act as key mediators linking nutritional cues to placental developmental gene expression.

Conclusions:

PPARs play a vital role in placental development by regulating gene expression in response to nutritional signals.
Understanding PPAR function is critical for comprehending developmental processes and metabolic regulation.