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Updated: May 13, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
Improving identification and treatment of atrial fibrillation
1Oxford Heart Centre, John Radcliffe Hospital, Oxford, UK.
Insights
Atrial fibrillation (AF), the most common heart arrhythmia, affects millions globally, increasing stroke risk five-fold. Early diagnosis and management are crucial for preventing serious complications like thromboembolism.
Area of Science:
- Cardiology
- Electrophysiology
- Public Health
Background:
- Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia.
- Prevalence increases significantly with age, affecting a substantial portion of older adults.
- AF encompasses paroxysmal, persistent, and permanent forms, with a natural progression from paroxysmal to persistent.
Purpose of the Study:
- To summarize the epidemiology, natural history, and clinical implications of atrial fibrillation.
- To highlight the importance of risk factor assessment and diagnostic evaluations in AF patients.
Main Methods:
- Review of existing literature on atrial fibrillation prevalence, risk factors, and consequences.
- Emphasis on clinical assessment including physical examination, thyroid function tests, and echocardiography as recommended by NICE guidelines.
Main Results:
- AF significantly increases the risk of systemic thromboembolism and stroke by five-fold.
- Loss of atrial contraction and altered clotting factors contribute to left atrial thrombus formation.
- Common risk factors are associated with AF development, though idiopathic cases exist.
Conclusions:
- Atrial fibrillation is a common and serious condition requiring comprehensive patient assessment.
- Prompt diagnosis and management are essential to mitigate the elevated risk of stroke and thromboembolic events.
Abstract:
Atrial fibrillation is the most common sustained cardiac arrhythmia. One in 40 of the over 45s, 1 in 20 of the over 65s, 1 in 10 of the over 75s and 1 in 5 of the over 85s will have paroxysmal, persistent or permanent atrial fibrillation. Paroxysmal atrial fibrillation episodes self-terminate. Persistent atrial fibrillation will not stop spontaneously but sinus rhythm may be restored with treatment, and permanent atrial fibrillation occurs when all attempts to restore sinus rhythm have been abandoned. The natural history is for paroxysmal episodes to increase until they become persistent. Although many individuals will have idiopathic atrial fibrillation with otherwise healthy hearts and no comorbidities, its development is associated with a number of common risk factors. Every patient with a diagnosis of atrial fibrillation should have a physical examination to assess BP and look for signs of valve disease and heart failure. It is routine to check thyroid function and NICE recommends echocardiographic assessment. Atrial fibrillation results in the loss of normal atrial contraction as well as influencing clotting factors. This may lead to the development of left atrial thrombus. The risk of systemic thromboembolism and stroke is increased five-fold in atrial fibrillation.
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