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Related Concept Videos

Classification of Illness01:17

Classification of Illness

The meaning of illness is individualized to each person who experiences an alteration in health. In contrast, disease is a medical term indicating a pathological change in the structure and function of the body or mind. It is a condition that has specific symptoms and boundaries.
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe and...
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Factors Affecting Illness01:18

Factors Affecting Illness

When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness, disability,...
Autism Spectrum Disorder01:19

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
Oppositional Defiant Disorder01:30

Oppositional Defiant Disorder

A persistent pattern of angry or irritable mood, defiant behavior, or vindictiveness characterizes Oppositional Defiant Disorder (ODD). Symptoms must occur over at least six months, involve interactions with individuals beyond siblings, and meet specific diagnostic criteria to be clinically significant. The disorder affects emotional regulation, social interactions, and behavior, often manifesting early in life and influencing long-term development and functioning.
Diagnostic Criteria and...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Related Experiment Video

Updated: May 13, 2026

Electromagnetic Source Imaging in Presurgical Evaluation of Children with Drug-Resistant Epilepsy
09:57

Electromagnetic Source Imaging in Presurgical Evaluation of Children with Drug-Resistant Epilepsy

Published on: September 20, 2024

[Frequently ill child syndrome].

M G Romantsov, I Iu Mel'nikova, I V Sarvilina

    Antibiotiki I Khimioterapiia = Antibiotics and Chemoterapy [Sic]
    |March 13, 2013
    PubMed
    Summary

    Cycloferon treatment effectively manages respiratory infections in frequently ill children (FIC). Proteomic analysis of blood plasma revealed key protein pathways sensitive to therapy, demonstrating the drug's immunoprophylactic benefits.

    Area of Science:

    • Immunology
    • Pediatrics
    • Proteomics

    Background:

    • Frequently ill children (FIC) experience recurrent respiratory tract infections.
    • Standard treatment protocols for FIC often require optimization for improved efficacy.
    • Understanding the molecular mechanisms underlying treatment response is crucial.

    Purpose of the Study:

    • To evaluate the efficacy of cycloferon in treating frequently ill children (FIC).
    • To assess the dynamics of the blood plasma proteomic profile as a biomarker for treatment efficacy.
    • To determine the role of cycloferon in nonspecific immunoprophylaxis for FIC.

    Main Methods:

    • Observation of FIC aged 4-10 years receiving standard cycloferon treatment.
    • Analysis of clinical data, infection index, and proteomic profiles (electrophoresis, mass spectrometry) before and after treatment.

    Related Experiment Videos

    Last Updated: May 13, 2026

    Electromagnetic Source Imaging in Presurgical Evaluation of Children with Drug-Resistant Epilepsy
    09:57

    Electromagnetic Source Imaging in Presurgical Evaluation of Children with Drug-Resistant Epilepsy

    Published on: September 20, 2024

  • Utilized a computer program complex for comprehensive data analysis.

    • Main Results:

    • Blood plasma proteomic profile changes, specifically Rho and Ras protein intensity and associated signal pathways, were sensitive indicators of therapy effectiveness.
    • Cycloferon administration demonstrated measurable impacts on these proteomic parameters.
    • The study identified specific proteomic signatures correlating with successful treatment outcomes.

    Conclusions:

    • The dynamics of blood plasma proteomic profiles, particularly Rho/Ras signaling, serve as reliable biomarkers for assessing cycloferon therapy and prophylaxis regimens in FIC.
    • Cycloferon exhibits significant epidemiologic efficacy as a nonspecific immunoprophylactic agent for FIC during peak seasons of respiratory infections and influenza.